Evaluation of human immunodeficiency virus (HIV) type 1 RNA levels in cerebrospinal fluid and viral resistance to zidovudine in children with HIV encephalopathy
Abstract
The amount of human immunodeficiency virus (HIV) type 1 RNA and the presence of a codon 215 mutation indicative of zidovudine resistance were evaluated in cerebrospinal fluid (CSF) and plasma obtained from HIV-1-infected children. The level of HIV-1 RNA in CSF was highest in children with severe enc …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
RNA
humans
pubmed abstract
nih
national institutes of health
national library of medicine
Child
Infant
preschool
Genes
polymerase chain reaction
follow-up studies
drug resistance
viral / analysis*
p a pizzo
microbial / genetics*
disease progression
cd4 lymphocyte count
hiv-1 / growth & development*
anti-hiv agents / therapeutic use*
hiv infections / drug therapy*
hiv infections / blood
hiv infections / virology*
zidovudine / therapeutic use*
point mutation
hiv core protein p24 / analysis
pmid:8940209
doi:10.1093/infdis/174.6.1200
s sei
s k stewart
aids dementia complex / blood
aids dementia complex / cerebrospinal fluid
aids dementia complex / drug therapy*
aids dementia complex / virology*
pol
hiv infections / cerebrospinal fluid
hiv-1 / genetics*
hiv-1 / pathogenicity
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260838
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