Pyogenic granuloma is a benign polypoidal or exophytic vascular lesion. It can occur at any age. The hypothetic etiologies include trauma, viral or hormonal factors. A total of 16 patients were enrolled in the study after taking consent. A total of 4 females and 12 males. All of them had single lesions which tend to bleed especially on touching. All of them were satisfied with the treatment. Regarding the immediate side effect, 6 patients developed transient bleeding, which was stopped after 15 minutes of pressing the bleeding areas. 1 patient reported recurrence after 3 months, which may be due to incomplete removal of the lesion. No other side effect was seen in all the patients. The combined continuous-wave/pulsed CO2 laser is our treatment of choice for pyogenic granuloma as it provides less bleeding than the other modalities.