It was studied and compared the antigens’’ frequency of blood groups in the reproductive horned Black and White cattle (n=542) and other five types of horned cattle: Steppe Red (n=54), Red Estonian (n=330), Simmental (n=34). Jersey (n=56), Ukrainian Grey (n=97), who were (directly or indirectly) involved in creation of horned Moldavian Black and White cattle. In tests 48-62 serums from 9-12 loci of sanguinary groups were used. It was calculated the genetic distance between the races and made up a dendrogram. The smallest genetic distance (0.1513) was obtained between the races Steppe Red and Red Estonian. The genetic distances between the improved race Black and White and races Steppe Red and Simmental was 0.1559 – 0.1708.