Children’s bodies are extremely sensitive to the action of various pathogens, toxins, chemicals, as well as mental stresses [1]. In today’s environmental, economic and social conditions, an increased antigenic load has changed the course of many diseases in children. First of all, at the present time such negative moments in children’s health should include an increased incidence of diagnosis of allergic and atopic conditions, prevalence of diseases, which are based on acute or chronic endotoxemia, a high incidence of comorbidity [2]. In this regard, an important pathogenetic moment of therapeutic and preventive efforts of pediatricians is minimizing the adverse effects of endotoxemia on the child’s body and improving the treatment of various diseases [1].The publication provides an overview of the clinical studies de­monstrating the experience of clinical application of Lymphomyosot, a combined bioregulatory drug known in the pediatric practice, in common diseases of childhood [3–5]. Lymphomyosot — a basic drainage combined bioregulatory drug that improves the lymph outflow from the tissues and organs, providing detoxification and immunomodulating effects, which creates conditions for the optimization of the course of inflammation and its completion. Lymphomyosot has a favorable safety profile and was well tole­rated [1, 2, 6–15]. The drug in drops dosage form is approved for use in neonates, solution for injections — from 6 years old.