The catalytic decomposition of N2O was investigated over Cu-Zn/ZnAl2O4 catalysts in the temperature range of 400–650 °C Catalytic samples have been prepared by wet impregnation method. Prepared catalysts were characterized using several techniques like BET surface area, X-ray diffraction (XRD), and Scanning electron microscopy (SEM). The Cu-Zn/ZnAl2O4 showed higher catalytic performance along with long term stability during N2O decomposition. The Cu-Zn/ZnAl2O4 catalysts yielded 100% N2O conversion at 650 °C. The Cu-Zn/ZnAl2O4 catalysts are promising for decrease this strong greenhouse gas in the chemical industry.