Electronic transport has been investigated in four-quantum-dot combination coupled to metal electrodes using the non-equilibrium Green’s function method, and curves I-V and conductance (dI/dV) were analyzed for special combination. We have showed that the emergence of negative differential conductivity is due to asymmetric distribution of quantum dots in the central region, existence of non-coupled dots (side quantum dots), and the interference effect. We found that more side quantum dots lead to more negative differential conductance.