Objective: The aim of this study was to evaluate the clinical efficacy of an herbal medi-cine, Piascledine, on the treatment of chronic periodontitis.Materials and Methods: Twenty-four patients with chronic periodontitis participated in this interventional case control investigation. After initial screening the subjects were di-vided into case and control groups. Clinical measurements including plaque index (PI), bleeding on probing (BOP), probing pocket depth (PPD), bone level (BL) and clinical at-tachment level (CAL) were recorded for both groups, before and one month after scaling and root planing (SRP). The case group received 300 mg Piascledine capsules once a day for three months and the control group was only treated with SRP. The measurements were repeated in both groups at the 3 and 6 month recall visits.Results: Improvements were observed in all clinical parameters in both groups during the study period. PI as a covariate factor showed no significant difference between the two groups (P>0.05). On the other hand CAL, BOP, PPD and BL showed reduction in all pa-tients, but no significant difference was found between the two groups.Conclusion: According to the results obtained in the present study, Piascledine does not seem to have a favorable effect in the treatment of chronic periodontitis.