sex differences of brain serotonin synthesis in patients with irritable bowel syndrome using α-[11c]methyl-l-tryptophan, positron emission tomography and statistical parametric mapping
Abstract
BACKGROUND: Irritable bowel syndrome (IBS) is the most common functional bowel disorder and has a strong predominance in women. Recent data suggest that the brain may play an important role in the pathophysiology of IBS in the brain-gut axis. It is strongly suspected that serotonin (5-HT), a neurotransmitter found in the brain and gut, may be related to the pathophysiology of IBS. It is reported that a 5-HT3 antagonist is effective only in female patients with diarrhea-predominant IBS.
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255032
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255032
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10.1155/2003/572127
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