Climate change and Land-Use Land-Cover change (LULC) has significantly displaced the local rainfall patterns and weather conditions in Pakistan. This has resulted in a different climate-related problem, particularly vector borne diseases. Dengue transmission has emerged as one of the most devastating and life threatening disease in Pakistan, causing hundreds of deaths since its first outbreak. This study is designed to understand and analyze the disease patterns across two distinct study regions, using Geographic Information System (GIS), Satellite Remote Sensing (RS) along with climate and socio-economic and demographics datasets. The datasets have been analyzed by using GIS statistical analysis techniques. As a result, maps, tables and graphs have been plotted to estimate the most significant parameters. These parameters have been assigned a contribution weight value to prepare a model and Threat Index Map (TIM) for the study areas. Finally, the model has been tested and verified against existing datasets for both study areas. This model can be used as a disease Early Warning System (EWS).