Purpose: an assessment of efficiency of complex treatment of periodontitis at women in a period of postmenopause with the use of zoledronic acid. Material and methods. Examination and treatment of 90 patients with a chronic generalized periodontitis against post-menopausal osteoporosis has been conducted. Material is processed statistically. Results. Application of preparations of zoledronic acid in complex treatment of system osteoporosis and periodontitis allows to reduce the frequency of recurrence of periodontal disease and to improve indicators of bone remodeling. Conclusion. In conclusion it is worth while determining that zoledronic acid in complex therapy of periodontitis is an effective method of drug correction of a mineral exchange before periodontological surgery.