The author of this article attempts to introduce specific interpersonal communication between the salesperson and his disabled client (customer). The article has been designed to have the most practical dimension. Instead of a theoretical analysis of the psychosocial factors that affect interpersonal relationships, the author has presented specific guidelines for dealing with people with various types and levels of disability. The author focuses on relations with the blind, the deaf, the physically disabled and the mentally or intellectually disabled, whichshould be used in business. These tips are based on the existing ideas, which are implemented in non-profit sectors.