The impacts of different microphysics and boundary schemes and terrain settings on the heavy rainfall over western Myanmar associated with the tropical cyclone (TC) ROANU (2016) are investigated using the Weather Research and Forecasting (WRF) model. The results show that the microphysics scheme of Purdue Lin (LIN) scheme produces the strongest cyclone. Six experiments with various combinations of microphysics and boundary schemes indicated that a combination of WRF Single-Moment 6-class (WSM6) scheme and Mellor-Yamada-Janjic (MYJ) best fits to the Joint Typhoon Warning Center (JTWC) data. WSM6-MYJ also performs the best for the track and intensity of rainfall and obtains the best statistics skill scores in the range of maximum rainfall intensity for 48-h. Sensitivity experiments on different terrain settings with Normal Rakhine Mountain (NRM), with Half of Rakhine Mountain (HRM), and Without Rakhine Mountain (WoRM) are designed with the use of WSM6-MYJ scheme. The track of TC ROANU moved northwestward in WoRM and HRM. Due to the presence of Rakhine Mountain, TC track moved into Myanmar and the peak rainfall occurred on the leeward side of the Mountain. In the absence of Rakhine Mountain, a shift in peak rainfall was observed in north side of the Mountain.