The research was conducted at the Public Polytechnic of Kupang. The purpose of this study in­­­­cluded getting overview of student interest in running entrepreneurship. The for­mu­­­­lation of the problem was whether attitudes and motivation fostered entrepre­neur­ial in­te­­­­rest of students. The research method was simple random sampling (random) sur­­­­vey with quantitative analysis approach. Data was collected with ques­tion­naires. Data was pr­­ocessed with SPSS. The research was used multiple linear reg­­ression. The results of this study indicated that the variable attitude and motivation no sig­­nificant effect on the in­­terest in entre­pre­neur­ship.