isolation and assessment of the in vitro anti-tumor activity of smenothiazole a and b, chlorinated thiazole-containing peptide/polyketides from the caribbean sponge, smenospongia aurea
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isolation and assessment of the in vitro anti-tumor activity of smenothiazole a and b, chlorinated thiazole-containing peptide/polyketides from the caribbean sponge, smenospongia aurea

;Germana Esposito;Roberta Teta;Roberta Miceli;Luca S. Ceccarelli;Gerardo Della Sala;Rosa Camerlingo;Elena Irollo;Alfonso Mangoni;Giuseppe Pirozzi;Valeria Costantino
jixie gongcheng xuebao/journal of mechanical engineering 2015 Vol. 13 pp. 444-459
199
esposito2015marineisolation

Abstract

The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (3) and B (4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism.

Keywords

apoptosis thiazole structure elucidation marine natural products mtt assaysbiology (general)

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DOI:
10.3390/md13010444
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http://www.mdpi.com/1660-3397/13/1/444

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ID: 248361
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