Aim The phytochemical and antimicrobial qualities of chloroform and ethanolic root extracts of Chrysophyllum albidum G. Don Holl, Dacryodes edulis H.J. Lam and Garcinia kola H was investigated. Method Routine methods were used. The test isolates utilized were; Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Aspergillus niger, Penicillium notatum, Mucor mucedo and Candida albicans. Results Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins and tannins. Both extracts showed broad spectrum of antimicrobial activities but chloroform extracts gave higher zones of inhibition compared to corresponding concentrations of ethanol extracts. Maximal inhibitory zones were shown by P. aeruginosa; 30.7 mm +/- 0.01 against G. kola chloroform root extract. Chloroform root extracts of G. kola were comparatively more potent against the test isolates than C. albidum and D. edulis root extracts. All the respective root extracts exhibited a greater antibacterial activity in comparison with the antifungal attributes. Conclusion All the respective root extracts showed a greater antibacterial activity in comparison with the antifungal attributes. [J Intercult Ethnopharmacol 2014; 3(1.000): 15-20]