In this study the flora of Eskişehir Hekimdağ (Bozdağ) were investigated. According to Davis's grid system, the research area lies in B3 square. The plant samples collected in this region and determined that there are 59 families, as well as 467 species and subspecies taxa belonging to 219 genera. The phytogeographical distribution is as follows: 49 Mediterranean, 31 Euro-Siberian, 19 Irano-Turanian, 6 Euxin and 362 unknown or other-regional elements. The largest families are Asteraceae (50), Fabaceae (38), Lamiaceae (24), Poaceae (21) and Liliaceae (18) in terms of the number of species and subspecies included. Genera represented by the highest number of species are Centaurea (7), Alyssum (6), Silene, Astragalus, Trifolium, Lathyrus ve Campanula (5) . The number of endemic taxa within the study area is 41 (10.86%). 13 taxa are new records for the B3 square.