The aim of this study was to optimize the sensory acceptability (SA) of an andean sweet bread made with different percentages of wheat flour (WF), quinoa flour (QF) and sugar (S) was optimized through Simplex-Centroid Design (SCD) and Desirability Function (DF). Ten treatments were performed, in which the mixture of different percentages of WF (28% - 52.5%), QF (0% - 24.5%) and S (17.5% - 42%) accounted for 70% of the dough formula. The evaluation of the SA was conducted in triplicate with 20 consumer panelists of sweet bread, applying an unstructured scale from 0 to 10. Statistical analysis of SCD reported that a cubic model successfully explained the effect of WF, QF and S on SA (p = 0.0529 ≈ 0.05 and R2 = 94.49%), analyzing the response surface was observed that the ranges of the percentage that optimize the SA were: 35.35% - 41.97% of WF, 7.11% - 11.03% QF and 20.44% - 24.61% of S. By DF was determined that the percentages that optimize the SA were: 40.25% of WF, 9.05% QF and 20.70% of S.