Purpose of this study is was to examine the effectiveness of dual focus schema therapy (DFST) in treatment of antisocial personality disorderded heroine dependent men. In Multiple baseline experimental single case study, three antisocial personality disorderded heroin dependent men were selected using Millon Clinical Multiaxial Inventory and Structured Clinical Interview for DSM-IV based on disorders axis II and purposeful sampling. The treatment program was carried out for 24 week and 28 sessions, with a follow-up period of 3 months subsequent to treatment termination. Subjects completed Maudsley Addiction Profile and Young Schema Questionnaire and data was analyzed by Reliable change index and percentage of improvement. Results showed that DFST significantly reduced Substtance use and risk behaviour and improved Physical and psychological health and Personal/social functioning. DFST has appropriate effectiveness in treatment of antisocial personality disorderded heroine dependent men.