In order to solve the problem of medical equipment image retrieval，an image retrieval method based on multi feature layer fusion is proposed. Process:This method using color moments to calculate the characteristics of color image，the LBP Operator is used to calculate the texture features of the image，using Fourier descriptors calculated image of the characters，the stratified weighted fusion method of the characteristics of three types of fusion within a similarity measure，and ultimately the formation of retrieval based on. Results and conclusions:According to the experimental study of the endoscopic image and CT image，the experimental results confirm the validity of the proposed method. With continuous improvement of the precision requirements of the proposed method in precision ratio was significantly higher than that of two single feature retrieval method for medical image retrieval.