Background and Aim: The present study aimed at investigating the effect of a 12-week aerobic water exercise and atorvastatin on of Atrial Natriuretic Peptide (ANP) and Brain Natriuretic Peptide (BNP) changes in older men with cardiovascular diseases. Materials and Methods: In the current study, 40 patients with cardiovascular disease, aged 50-65yrs, who were volunteers for the research were divided in to four equal groups including1.exercise, 2.exercise plus atorvastatin, 3.atorvastatin, and 4.control. Then, blood was taken before and after the interventions. Groups 1 and 2 performed the specific water aerobic exercise 3 times a week for 12 weeks. Group 3 took 20mg of atorvastatin daily under a physician Water aerobic exercise lasted 12 weeks, 3 periods a week, with intensity of 55-60% of heart-beat. Every week, due to overtax principle, 3.5 minutes was added to exercise period. In order to determine the difference between pre-test and post-test, dependent T was applied. Intergroup difference was determined through ANOVA using Tukey for post-test; (P≤0.05). Results: ANOVA application revealed that mean of functional variables in pre-test compared to that of post-test was significantly different. Mean post-test of BNP in the four groups exercise, atorvastatin, exercise plus atorvastatin and control was P= 0.001, P=0.002, P=0.000, respectively. But mean post-test of ANP in the above mentioned groups was P=0.022, P=0.001, P=0.000, respectively. Conclusion: Aerobic exercises together with daily taking of atorvastatin can have significant effects on decreasing natriuretic peptides and CVDs.