The article is dedicated to the peculiarities of innovative investment support for domestic zero waste agriculture under conditions of modern social and economic transformations. It is established that the development of innovative investment support for zero waste agriculture is a decisive factor in achieving the goal of competitive, resource saving and environmentally safe production in agribusiness. The main problems of innovative investment support for zero waste agriculture are determined. The main directions of the state innovation policy on the introduction of zero waste agriculture in Ukraine are determined. It is proved that an increase of innovative investment support for zero waste agriculture will contribute to a technical, technological, organizational, and economic renewal of agribusiness, and as a result —the manufacturing of competitive products for the domestic and world markets and ensuring of the country’s food security.