The scope of wing optimization is to design a structure that meets all the airworthiness demands while minimizing its weight. This paper introduces a review for the most important optimization design tools of composite wings with multiple load cases and large scale design variables. Each discipline resorts to accurate design to ensure better performance. Accurate design and multidisciplinary optimization design for wings need large scale design variables. The structural design of an airframe is determined by multidisciplinary criteria (stress, fatigue, buckling, control surface effectiveness, flutter and weight etc.). Several thousands of structural sizes of stringers, panels, ribs etc. have to be determined considering hundreds of thousands of requirements to find an optimum solution, i.e. a design fulfilling all requirements with a minimum weight or minimum cost respectively.