The goal of the study was to develop methods for diagnosing oxygenation disorders and thoracopulmonary restriction during respiratory support and to evaluate their efficacy. 206 patients receiving prolonged respiratory support were included in the study. The developed method of diagnosing oxygenation disorders during respiratory support is 1.4 times faster than the Murrays lung ingury score. Sensitivity and specificity oftheauthorsmethod fordiagnosing thoracopulmonaryrestrictionamounted to0.897and 0.838 respectively as compared to 0.47 and 0.189 achieved by using the Murrays lung injury score. A new modification of the acute lung injury score including a respiratory function calculator was also developed.