Yongchun Shen,1 Shaoguang Huang,2 Jian Kang,3 Jiangtao Lin,4 Kefang Lai,5 Yongchang Sun,6 Wei Xiao,7 Lan Yang,8 Wanzhen Yao,6 Shaoxi Cai,9 Kewu Huang,10 Fuqiang Wen1 1Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu, 2Department of Pulmonary Disease, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, 3Department of Respiratory Medicine, Institute of Respiratory Diseases, The First Affiliated Hospital of China Medical University, Shenyang, 4Department of Respiratory Diseases, China-Japan Friendship Hospital, Beijing, 5State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 6Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, 7Department of Respiratory Medicine, Qilu Hospital of Shandong University, Jinan, 8Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 9Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 10Division of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China Abstract: Airway mucus hypersecretion is one of the most important characteristics of chronic airway inflammatory diseases. Evaluating and managing airway mucus hypersecretion is of great importance for patients with chronic airway inflammatory diseases. This consensus statement describes the pathogenesis, clinical features, and the management of airway mucus hypersecretion in patients with chronic airway inflammatory diseases in the People’s Republic of China. The statement has been written particularly for respiratory researchers, pulmonary physicians, and patients. Keywords: mucus, COPD, asthma, bronchiectasis, cystic fibrosis, treatment