Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

Bentley, Amy R;Sung, Yun J;Brown, Michael R;Winkler, Thomas W;Kraja, Aldi T;Ntalla, Ioanna;Schwander, Karen;Chasman, Daniel I;Lim, Elise;Deng, Xuan;Guo, Xiuqing;Liu, Jingmin;Lu, Yingchang;Cheng, Ching-Yu;Sim, Xueling;Vojinovic, Dina;Huffman, Jennifer E;Musani, Solomon K;Li, Changwei;Feitosa, Mary F;Richard, Melissa A;Noordam, Raymond;Baker, Jenna;Chen, Guanjie;Aschard, Hugues;Bartz, Traci M;Ding, Jingzhong;Dorajoo, Rajkumar;Manning, Alisa K;Rankinen, Tuomo;Smith, Albert V;Tajuddin, Salman M;Zhao, Wei;Graff, Mariaelisa;Alver, Maris;Boissel, Mathilde;Chai, Jin Fang;Chen, Xu;Divers, Jasmin;Evangelou, Evangelos;Gao, Chuan;Goel, Anuj;Hagemeijer, Yanick;Harris, Sarah E;Hartwig, Fernando P;He, Meian;Horimoto, Andrea R V R;Hsu, Fang-Chi;Hung, Yi-Jen;Jackson, Anne U;Kasturiratne, Anuradhani;Komulainen, Pirjo;Kühnel, Brigitte;Leander, Karin;Lin, Keng-Hung;Luan, Jian'an;Lyytikäinen, Leo-Pekka;Matoba, Nana;Nolte, Ilja M;Pietzner, Maik;Prins, Bram;Riaz, Muhammad;Robino, Antonietta;Said, M Abdullah;Schupf, Nicole;Scott, Robert A;Sofer, Tamar;Stancáková, Alena;Takeuchi, Fumihiko;Tayo, Bamidele O;van der Most, Peter J;Varga, Tibor V;Wang, Tzung-Dau;Wang, Yajuan;Ware, Erin B;Wen, Wanqing;Xiang, Yong-Bing;Yanek, Lisa R;Zhang, Weihua;Zhao, Jing Hua;Adeyemo, Adebowale;Afaq, Saima;Amin, Najaf;Amini, Marzyeh;Arking, Dan E;Arzumanyan, Zorayr;Aung, Tin;Ballantyne, Christie;Barr, R Graham;Bielak, Lawrence F;Boerwinkle, Eric;Bottinger, Erwin P;Broeckel, Ulrich;Brown, Morris;Cade, Brian E;Campbell, Archie;Canouil, Mickaël;Charumathi, Sabanayagam;Chen, Yii-Der Ida;Christensen, Kaare;, ;Concas, Maria Pina;Connell, John M;de Las Fuentes, Lisa;de Silva, H Janaka;de Vries, Paul S;Doumatey, Ayo;Duan, Qing;Eaton, Charles B;Eppinga, Ruben N;Faul, Jessica D;Floyd, James S;Forouhi, Nita G;Forrester, Terrence;Friedlander, Yechiel;Gandin, Ilaria;Gao, He;Ghanbari, Mohsen;Gharib, Sina A;Gigante, Bruna;Giulianini, Franco;Grabe, Hans J;Gu, C Charles;Harris, Tamara B;Heikkinen, Sami;Heng, Chew-Kiat;Hirata, Makoto;Hixson, James E;Ikram, M Arfan;, ;Jia, Yucheng;Joehanes, Roby;Johnson, Craig;Jonas, Jost Bruno;Justice, Anne E;Katsuya, Tomohiro;Khor, Chiea Chuen;Kilpeläinen, Tuomas O;Koh, Woon-Puay;Kolcic, Ivana;Kooperberg, Charles;Krieger, Jose E;Kritchevsky, Stephen B;Kubo, Michiaki;Kuusisto, Johanna;Lakka, Timo A;Langefeld, Carl D;Langenberg, Claudia;Launer, Lenore J;Lehne, Benjamin;Lewis, Cora E;Li, Yize;Liang, Jingjing;Lin, Shiow;Liu, Ching-Ti;Liu, Jianjun;Liu, Kiang;Loh, Marie;Lohman, Kurt K;Louie, Tin;Luzzi, Anna;Mägi, Reedik;Mahajan, Anubha;Manichaikul, Ani W;McKenzie, Colin A;Meitinger, Thomas;Metspalu, Andres;Milaneschi, Yuri;Milani, Lili;Mohlke, Karen L;Momozawa, Yukihide;Morris, Andrew P;Murray, Alison D;Nalls, Mike A;Nauck, Matthias;Nelson, Christopher P;North, Kari E;O'Connell, Jeffrey R;Palmer, Nicholette D;Papanicolau, George J;Pedersen, Nancy L;Peters, Annette;Peyser, Patricia A;Polasek, Ozren;Poulter, Neil;Raitakari, Olli T;Reiner, Alex P;Renström, Frida;Rice, Treva K;Rich, Stephen S;Robinson, Jennifer G;Rose, Lynda M;Rosendaal, Frits R;Rudan, Igor;Schmidt, Carsten O;Schreiner, Pamela J;Scott, William R;Sever, Peter;Shi, Yuan;Sidney, Stephen;Sims, Mario;Smith, Jennifer A;Snieder, Harold;Starr, John M;Strauch, Konstantin;Stringham, Heather M;Tan, Nicholas Y Q;Tang, Hua;Taylor, Kent D;Teo, Yik Ying;Tham, Yih Chung;Tiemeier, Henning;Turner, Stephen T;Uitterlinden, André G;, ;van Heemst, Diana;Waldenberger, Melanie;Wang, Heming;Wang, Lan;Wang, Lihua;Wei, Wen Bin;Williams, Christine A;Wilson, Gregory;Wojczynski, Mary K;Yao, Jie;Young, Kristin;Yu, Caizheng;Yuan, Jian-Min;Zhou, Jie;Zonderman, Alan B;Becker, Diane M;Boehnke, Michael;Bowden, Donald W;Chambers, John C;Cooper, Richard S;de Faire, Ulf;Deary, Ian J;Elliott, Paul;Esko, Tõnu;Farrall, Martin;Franks, Paul W;Freedman, Barry I;Froguel, Philippe;Gasparini, Paolo;Gieger, Christian;Horta, Bernardo L;Juang, Jyh-Ming Jimmy;Kamatani, Yoichiro;Kammerer, Candace M;Kato, Norihiro;Kooner, Jaspal S;Laakso, Markku;Laurie, Cathy C;Lee, I-Te;Lehtimäki, Terho;, ;Magnusson, Patrik K E;Oldehinkel, Albertine J;Penninx, Brenda W J H;Pereira, Alexandre C;Rauramaa, Rainer;Redline, Susan;Samani, Nilesh J;Scott, James;Shu, Xiao-Ou;van der Harst, Pim;Wagenknecht, Lynne E;Wang, Jun-Sing;Wang, Ya Xing;Wareham, Nicholas J;Watkins, Hugh;Weir, David R;Wickremasinghe, Ananda R;Wu, Tangchun;Zeggini, Eleftheria;Zheng, Wei;Bouchard, Claude;Evans, Michele K;Gudnason, Vilmundur;Kardia, Sharon L R;Liu, Yongmei;Psaty, Bruce M;Ridker, Paul M;van Dam, Rob M;Mook-Kanamori, Dennis O;Fornage, Myriam;Province, Michael A;Kelly, Tanika N;Fox, Ervin R;Hayward, Caroline;van Duijn, Cornelia M;Tai, E Shyong;Wong, Tien Yin;Loos, Ruth J F;Franceschini, Nora;Rotter, Jerome I;Zhu, Xiaofeng;Bierut, Laura J;Gauderman, W James;Rice, Kenneth;Munroe, Patricia B;Morrison, Alanna C;Rao, Dabeeru C;Rotimi, Charles N;Cupples, L Adrienne;
nature genetics 2019 Vol. 51 pp. 636-648
246
bentley2019multiancestrynature

Abstract

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

Citation

ID: 22844
Ref Key: bentley2019multiancestrynature
Use this key to autocite in SciMatic or Thesis Manager

References

Blockchain Verification

Account:
NFT Contract Address:
0x95644003c57E6F55A65596E3D9Eac6813e3566dA
Article ID:
22844
Unique Identifier:
10.1038/s41588-019-0378-y
Network:
Scimatic Chain (ID: 481)
Loading...
Blockchain Readiness Checklist
Authors
Abstract
Journal Name
Year
Title
5/5
Creates 1,000,000 NFT tokens for this article
Token Features:
  • ERC-1155 Standard NFT
  • 1 Million Supply per Article
  • Transferable via MetaMask
  • Permanent Blockchain Record
Blockchain QR Code
Scan with Saymatik Web3.0 Wallet

Saymatik Web3.0 Wallet