Introduction: Critical thinking improves students’ problem solving ability and is one of the main outputs of academic centers. It has an important role in medical sciences as the students studying these branches of science are getting ready to attend clinical work. Critical thinking helps to convey skills from class to clinic. This study aimed at investigating the relationship between critical thinking skills with creativity and academic achievement in students Qom University of Medical Sciences. Methods: In this descriptive­- correlation study was conducted on 303 students in Qom University of Medical Sciences were  selected through stratified random sampling method with considering gender. Data were collected through two standard questionnaires on critical thinking skills CCTST form(B) and creativity Abedi. Data were analyzed using descriptive statistics methods, Pearson correlation and independent t-test, and multiple regression analysis. Results: The results of Pearson correlation test showed that there was significant positive relationship between critical thinking skills with creativity(P=0/000, r=0/267). But There was no a significant relationship between critical thinking skills with academic achievement(P=0/284, r=0/081) and creativity with academic achieveme (P=0/741, r=0/025). According to independent t-test results, there was no significant difference between male and female students’ average scores in critical thinking skills and creativity. But there was a significant difference between male and female students’ in academic achievement. Also multiple regression analysis revealed that only creativity predicted critical thinking skills significantly Conclusion: Critical thinking skills improving the process can improve students' creativity level. critical thinking skills affects creativity. Such relationship is increasingly important in students of medicine and health sciences