treatment resistance mechanisms of malignant glioma tumor stem cells
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treatment resistance mechanisms of malignant glioma tumor stem cells

;Philip G.R. Schmalz;John K. Park;Michael J. Shen
The Journal of investigative dermatology 2011 Vol. 3 pp. 621-635
199
schmalz2011cancerstreatment

Abstract

Malignant gliomas are highly lethal because of their resistance to conventional treatments. Recent evidence suggests that a minor subpopulation of cells with stem cell properties reside within these tumors. These tumor stem cells are more resistant to radiation and chemotherapies than their counterpart differentiated tumor cells and may underlie the persistence and recurrence of tumors following treatment. The various mechanisms by which tumor stem cells avoid or repair the damaging effects of cancer therapies are discussed.

Keywords

glioblastoma Chemotherapy malignant glioma Oncology including cancer and carcinogens tumors radiation therapyneoplasms

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DOI:
10.3390/cancers3010621
URL:
http://www.mdpi.com/2072-6694/3/1/621/

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ID: 228023
Ref Key: schmalz2011cancerstreatment
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