Studies have identified that workers in paint industries are vulnerable to disorders due to the exposure to toxic chemicals and solvents. Such disorders are often missed. Social health security is incomplete, especially in our country, until such issues are addressed. Our aim was to study the alterations in biochemical parameters among paint workers in comparison with healthy subjects, in Puducherry. It was a cross-sectional study with 2 groups. Group A comprised 17 paint workers and Group B, 10 healthy controls in Puducherry. Blood samples and urine samples were collected from both the groups. All blood and urine parameters were estimated an using automated biochemical analyzer. Statistical analysis was employed. Our study showed adverse renal parameters (P<0.05) in the paint workers as compared with the control group. Contrary to conventional expectation, our study did not show evidence of obvious liver damage.