The purpose of this study was to accomplish a comparative assessment between the immunohistochemical and immunocytochemical expression of p16 protein and of L1capsid protein respectively of HPV, high grade and low grade squamous intraepithelial lesion, in order to determine, by morph-clinical  correlations, their practical applicability in diagnosing and the subsequent monitoring of the patients. For the cases studied, HPV L1 capsid protein was present in 66.7% of LSIL, 17.6% of HSIL and 18.2% of ASCUS. From all cervical biopsies, p16 biomarker was positive for 54.8% of LSIL, 98% of HSIL and 45.5% of ASCUS. The biggest part of cervical cancer cases are caused by HPV virus infection. HPV vaccine protects against 4 HPV roots that cause about 70% of cervical cancer cases.