The objective is to describe the social management of knowledge through research and innovation networks to promote social inclusion. The reflection of the exploratory stage is presented within the doctoral thesis analyzing the challenges of the universities in the achievement of social inclusion with networks of research and innovation. A descriptive work was done, with documentary tracking, systematization and analysis. The findings show that it is necessary to articulate efforts in interdisciplinary and transdisciplinary networks with different actors: state, company, education, scientists, technologists and vulnerable, excluded populations, to build policies and strategies for social inclusion.