This is to lay down an approach to develop tourism and cultural heritage through higher education and entrepreneurship development for economies in transition: The case of Tunisia. There is a need to provide incentives to people to have favorable preferences toward a tourism based in part on cultural heritage in a phase where everything is being under construction institutions, legislations, and relationships alike. Cultural heritage and tourism development may be enhanced by a diversification strategy to enrich the image of local touristic destinations (diversification of site visits, purchases of new products, new circuits, and discovery of monumental heritage, museum, park and gardens, natural sites). Moreover, it is of great importance to invest in youth entrepreneurship development to orient toward business creation and development in the domain of tourism and cultural heritage.