A neural network controller design is studied for a class of nonlinear chaotic systems with uncertain parameters. Because the chaos phenomena are often in this class of systems, it is indispensable to control this class of systems. At the same time, due to the presence of uncertainties in the chaotic systems, it results in the difficulties of the controller design. The neural networks are employed to estimate the uncertainties of the systems and a controller is designed to overcome the chaos phenomena. The main contribution of this paper is that the adaptation law can be determined via the gradient descent algorithm to minimize a cost function of error. It can prove the stability of the closed-loop system. The numerical simulation is specified to pinpoint the validation of the approach.