This paper is part of a general research project on the role that chemistry played in transforming experimental pharmacology during nineteenth-century Spain. Within this general framework, this paper deals with the main characteristics of chemistry textbooks written by Pedro Gutiérrez Bueno (1745-1822), a pharmacist who taught chemistry in several institutions during the late eighteenth century. In an earlier paper, we have analysed the intended public of the first edition of Gutiérrez Bueno`s textbook. This paper deals with the changing institutional context in which the second edition was published. This issue is closely connected with substantial transformations in the relationship between chemistry and pharmacy that took place during this period. Therefore, Gutiérrez Bueno`s ideas about this problem are examined as well as his major role in appropriating some of Antoine Fourcroy`s views on chemistry and pharmacy.