functional connectivity in in vitro neuronal assemblies
;Daniele ePoli;Vito Paolo Pastore;Paolo eMassobrio
Fish physiology and biochemistry2015Vol. 9pp. -
185
epoli2015frontiersfunctional
Abstract
Complex network topologies represent the necessary substrate to support complex brain functions. In this work, we reviewed in vitro neuronal networks coupled to Micro-Electrode Arrays (MEAs) as biological substrate. Networks of dissociated neurons developing in vitro and coupled to MEAs, represent a valid experimental model for studying the mechanisms governing the formation, organization and conservation of neuronal cell assemblies. In this review, we present some examples of the use of statistical Cluster Coefficients and Small World indices to infer topological rules underlying the dynamics exhibited by homogeneous and engineered neuronal networks.