The construction of a cyber physical system in a power grid provides more potential control strategies for the power grid. With the rapid employment of intelligent terminal equipment (e.g., smart meters and intelligent appliances) in the environment of a smart grid, abundant dynamic response information could be introduced to support a secure and stable power system. Combining demand response technology with the traditional under-frequency load shedding (UFLS) scheme, a new UFLS strategy-determining method involving intelligent appliances is put forward to achieve the coordinated control of quick response resources and the traditional control resources. Based on this method, intelligent appliances can be used to meet the regulatory requirements of system operation in advance and prevent significant frequency drop, thereby improving the flexibility and stability of the system. Time-domain simulation verifies the effectiveness of the scheme, which is able to mitigate frequency drop and reduce the amount of load shedding.