Septicemia is an inflammatory host response to infection, which rapidly progresses to multiorgan failure and may develop skin lesions. The skin lesions of septicemia often present as purpura, purpura fulminans, and bleeding from erosion. However, there is a paucity of literature describing the features of septicemia both on the intact and eroded skin. The diagnosis of septicemia by identifying its features on the skin is very important for a dermatologist. This case report describes the dermatological changes of septicemia on the eroded skin of pemphigus vulgaris under treatment.