Aim : Peyronie′s disease is a disorder of the connective tissue involving the soft tissue surface of the penis. There are various modalities to treat this disease ranging from intralesional injections to surgical removal. Extra Corporeal Shock Wave Therapy is a recent non-surgical modality to treat this disease. So, the aim of the present study was to check the efficacy of Shock Wave Therapy on Peyronie′s Disease. Materials and Method: Thirty male patients were selected from the outpatient department. 300 shock waves were applied in 3 sets for 20 minutes. They were delivered at 009mJ/mm2 and frequency of 120/min. Data analysis was carried out by SPSS version17. Results: Forty percent patients had penile curvature. Penile plaque was found in all patients where 50% had it on dorsum of shaft, 33% on lateral and 17% on ventral surface. Calcified type of plaque was most commonly found (70%) in these patients. Shock wave therapy reduced the pain as well as the plaque size. There was significant reduction in the curvature of penis after treatment. Conclusion: The result of this study concluded that extra corporeal shock wave therapy can be a new non- invasive modality to treat connective tissue diseases like Peyroni′s Disease.