nonlinearities in drug release process from polymeric microparticles: long-time-scale behaviour

nonlinearities in drug release process from polymeric microparticles: long-time-scale behaviour

;Elena Simona Bacaita;Costica Bejinariu;Borsos Zoltan;Catalina Peptu;Gabriela Andrei;Marcel Popa;Daniela Magop;Maricel Agop
Chemico-biological interactions 2012 Vol. 2012 pp. -
157
bacaita2012journalnonlinearities

Abstract

A theoretical model of the drug release process from polymeric microparticles (a particular type of polymer matrix), through dispersive fractal approximation of motion, is built. As a result, the drug release process takes place through cnoidal oscillations modes of a normalized concentration field. This indicates that, in the case of long-time-scale evolutions, the drug particles assemble in a lattice of nonlinear oscillators occur macroscopically, through variations of drug concentration. The model is validated by experimental results.

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