constituintes químicos de parmotrema lichexanthonicum eliasaro & adler: isolamento, modificações estruturais e avaliação das atividades antibiótica e citotóxica chemical constituents of parmotrema lichexanthonicum eliasaro & adler: isolation, structure modification and evaluation of antibiotic and cytotoxic activities
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constituintes químicos de parmotrema lichexanthonicum eliasaro & adler: isolamento, modificações estruturais e avaliação das atividades antibiótica e citotóxica chemical constituents of parmotrema lichexanthonicum eliasaro & adler: isolation, structure modification and evaluation of antibiotic and cytotoxic activities

;Ana C. Micheletti;Adilson Beatriz;Dênis Pires de Lima;Neli K. Honda;Cláudia do Ó Pessoa;Manoel Odorico de Moraes;Letícia Veras Lotufo;Hemerson Iury Ferreira Magalhães;Nádia C. P. Carvalho
greece and rome 2009 Vol. 32 pp. 12-20
96
micheletti2009qumicaconstituintes

Abstract

From the lichen Parmotrema lichexantonicum were isolated the depsidone salazinic acid, the xanthone lichexanthone, and the depside atranorin. The two major compounds, salazinic acid and lichexanthone, were selected for structure modifications. Salazinic acid afforded O-alkyl salazinic acids, some of them potentially cytotoxic against tumor cell lines (HCT-8, SF-295 and MDA/ MB - 435). From lichexanthone were obtained norlichexanthone, 3-O-methylnorlichexanthone, 3-O-methyl-6-O-prenylnorlichexanthone, 3,6-di-O-prenyl-norlichexanthone, 3,6-bis[(3,3-dimethyloxyran-2-il)methoxy]-1-hydroxy-8-methyl-9H-xanten-9-one and 3,6-bis[3-(dimethylamine)propoxy]-1-hydroxy-8-methyl-9H-xanten-9-one. The last compound was the most active against S. aureus.

Keywords

lichenschemistry

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DOI:
10.1590/S0100-40422009000100003
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http://www.scielo.br/scielo.php?script=sci_arttext...

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