In this paper, a square-lattice photonic crystal fiber based on optofluidic infiltration technique is proposed for supercontinuum generation. Using this approach, without nano-scale variation in the geometry of the photonic crystal fiber, ultra-flattened near zero dispersion centered about 1500 nm will be achieved. By choosing the suitable refractive index of the liquid to infiltrate into the air-holes of the fiber, the supercontinuum will be generated for 50 fs input optical pulse of 1550 nm central wavelength with 20 kW peak power. We numerically demonstrate that this approach allows one to obtain more than two-octave spanning of supercontinuum from 800 to 2000 nm. The spectral slicing of this spectrum has also been proposed as a simple way to create multi-wavelength optical sources for dense wavelength division multiplexing.