The authors describe a case of sclerosing angiomatoid nodular transformation (SANT) of the spleen treated at the 2ndDepartment of Surgery, Jagiellonian University, Medical College. The patient was a 23-year-old woman. Clinically shepresented with 2-year history of recurrent mild fever, diffuse joint pain, abdominal discomfort and iron deficiencyanaemia of chronic disease. The laboratory tests revealed a non-characteristic chronic inflammatory response.A splenic solid lesion 9 cm in diameter was found on abdominal computed tomography. The patient underwentuneventful laparoscopic resection of the upper half of the splenic parenchyma. The resected tumour showed characteristichistological and immunophenotypical findings of SANT as previously described in the literature. In long-termfollow-up, improvement of preoperative symptoms and abnormalities in the blood tests was documented.