The RNG k-ε turbulence model combined with cavitation model was used to simulate unsteady cavitating flows inside a double-suction centrifugal pump under different flow rate conditions based on hexahedral structured grid. The numerical external characteristic performances agree well with the experimental performances. The predicted results show that the turbulence kinetic energy and the turbulence dissipation rate inside the impeller at design flow rate are lower than those at other off-design flow rates, which are caused by various vortexes. Based on frequency-domain analyses in the volute casing, the blade passing frequency is the dominant one of the pressure fluctuations except the vicinity of volute tongue for all operating cases, and the dominant frequency near the volute tongue ranges from 0 to 0.5 times the blade passing frequency for other off-design points, while the blade passing one near the volute tongue is the dominant one of the pressure fluctuations at design point. The increase of flow rate reduces the pressure fluctuations amplitude. For cavitation cases, the blade loading of the middle streamline increases a bit during the initial stage, but, for serious cavitation, the blade loading near the blade inlet reduces to 0 and even negative values, and the serious cavitation bubbles block the blade channels, which results in a sharp drop in pump head. Under noncavitation condition, the predicted power related to the pressure in the impeller channels increases from the inlet to the exit, while, under different cavitation conditions at the design flow rate, these power-transformation distributions in the impeller channels show that these power conversions are affected by the available NPSHa and the corresponding work in leading regions of the blades increases increases gradually a bit, and then it increases sharply in the middle regions, but it decreases in the blade trailing regions and is greatly influenced by secondary flows.