Located in the southeastern China and northern Vietnam, the Red River is an important international trans-boundary river that has experienced rapid deforestation and environmental changes over the past decades. We conducted attribution analysis of impacts of various environmental changes on streamflow and sediment load. The contribution of reclassified environmental changes to total change of the streamflow and sediment load was separated. Land cover change based on climate-induced and human-induced indicators were defined. We found that human-induced land cover change was the main factor affecting changes of the streamflow and sediment load. Changes of the land cover were more pronounced in the dry season than in the wet season whereas sediment load changed more in the wet season than in the dry season. In addition, changes in sediment load were mainly caused by human-induced land cover change and the changes of land cover were more influential on sediment load than on streamflow in the Red River basin.