The article discusses the conceptual set of economic-mathematical problems, the solution of which allows to evaluate the optimized estimated efficiency of innovative regional clusters, bringing together mining and processing raw materials production, in its three forms - for the regional economy, for the cluster itself as an integration structure that creates a systematic and synergetic effect for its participants; for each of the cluster members, pending the manifestation of the effect of the diversification of their activities, that is, in an article talking about the triune efficiency created or existing cluster. As an example, the article is considered a pilot innovative territorial clusters «Complex processing of coal and industrial waste» in Kemerovo region