Objective: To explore the effect of partial body weight support training (PBWST) on the cardiac function, neuroendocrine function, and vascular endothelial function in patients with early heart failure. Methods: A total of 98 patients with early heart failure who were admitted in our hospital were included in the study and randomized into the observation group and the control group. The patients in the control group were given routine drugs and rehabilitation. On this basis, the patients in the observation group were given PBWST. The patients in the two groups were treated for 3 months. The changes of cardiac function, neuroendocrine function, and vascular endothelial function indicators before and after rehabilitation in the two groups were detected. Results: LVESD and ESV after training in the two groups were significantly reduced. LVESD and ESV after training in the observation group were significantly lower than those in the control group. SV, CI, LVEF, and FS after training in the observation group were significantly elevated when compared with before training. LVEF and FS after training in the observation group were significantly higher than those in the control group. LVEF after training in the control group was significantly elevated. PRA, Ang Ⅱ, ET, and ALD levels after training in the observation group were significantly reduced, while NO was significantly elevated, and the improvement of the above indicators was significantly superior to that in the control group. Conclusions: PBWST can improve the cardiac function in patients with early heart failure, inhibit the excessive activation of neuroendocrine system, and protect the vascular endothelial function in order to enhance the clinical efficacy.