The structure of infertility causes in 100 couples (200 people) with infertility in Tashkent and Tashkent region (50 families each) has been studied. It is found that in women surveyed in the origin of infertility, hormonal dysfunction takes principal place (diffuse goiter with subclinical hypothyroidism, ovarian failure with menstrual disorders, polycystic ovary syndrome, hyperandrogenism, luteal phase deficiency, impaired folliculogenesis), as well as inflammatory diseases of the genitourinary system (TORCH infections). In the men surveyed in the origin of infertility, hormonal dysfunction takes principal place (androgen deficiency associated with excess body weight, impaired spermatogenesis, hypergonadotropic and hypogonadotropic hypogonadism).