Irrigation in the Mediterranean is of vital importance for food security, employment and economic development. This study systematically assesses how climate change and increases in atmospheric CO₂ concentrations may affect irrigation requirements in the Mediterranean region by 2080–2090. Future demographic change and technological improvements in irrigation systems are taken into account, as is the spread of climate forcing, warming levels and potential realization of the CO₂-fertilization effect. Vegetation growth, phenology, agricultural production and irrigation water requirements and withdrawal were simulated with the process-based ecohydrological and agro-ecosystem model LPJmL (Lund–Potsdam–Jena managed Land) after an extensive development that comprised the improved representation of Mediterranean crops. At present the Mediterranean region could save 35 % of water by implementing more efficient irrigation and conveyance systems. Some countries such as Syria, Egypt and Turkey have a higher savings potential than others. Currently some crops, especially sugar cane and agricultural trees, consume on average more irrigation water per hectare than annual crops. Different crops show different magnitudes of changes in net irrigation requirements due to climate change, the increases being most pronounced in agricultural trees. The Mediterranean area as a whole may face an increase in gross irrigation requirements between 4 and 18 % from climate change alone if irrigation systems and conveyance are not improved (4 and 18 % with 2 °C global warming combined with the full CO₂-fertilization effect and 5 °C global warming combined with no CO₂-fertilization effect, respectively). Population growth increases these numbers to 22 and 74 %, respectively, affecting mainly the southern and eastern Mediterranean. However, improved irrigation technologies and conveyance systems have a large water saving potential, especially in the eastern Mediterranean, and may be able to compensate to some degree for the increases due to climate change and population growth. Both subregions would need around 35 % more water than today if they implement some degree of modernization of irrigation and conveyance systems and benefit from the CO₂-fertilization effect. Nevertheless, water scarcity may pose further challenges to the agricultural sector: Algeria, Libya, Israel, Jordan, Lebanon, Syria, Serbia, Morocco, Tunisia and Spain have a high risk of not being able to sustainably meet future irrigation water requirements in some scenarios. The results presented in this study point to the necessity of performing further research on climate-friendly agro-ecosystems in order to assess, on the one hand, their degree of resilience to climate shocks and, on the other hand, their adaptation potential when confronted with higher temperatures and changes in water availability.