In a complex, dynamic and turbulent world the main confrontation is between fundamentally different values, between democracy and totalitarianism, and it is determined by the major aggression of international terrorism, of religious extremist origin. The objective of the paper is the presentation of geopolitical changes in the Middle East and the factors that influence them. In an increasingly globalized world one cannot stand by and be indifferent to what happens so close to Europe. In this environment, no country can stay isolated or stay neutral, no country is immune and no one should remain out of the global processes. As a result, the international security tends more and more to show its indivisible feature, and the international community is increasingly aware of its global responsibilities. In the undertaken study we conclude that the major tendencies, that govern the global developments in the post bipolar era, create legitimate concerns, posing new challenges, offering opportunities and presenting risks to national values and interests. This paper is intended to focus on: the reconfiguration of the area in the Asian West in the early 21st century; the Muslim world with its issues (see the Iran's geopolitical position); globalization, major factor in determining the behavior of key international actors.