Background and aimsBackground and Aims: MSDs are very common in public vehicle drivers. As regards, drivers spend long time to this occupation; these disorders will be chronic and results to MSDs. According to the past researches, one of the main reasons for accidents is MSDs and low back pain. In this research, we survey the relation between anthropometric indices and Musculoskeletal Disorders in public vehicle drivers.Methodsfor this descriptive and analytic study 95 bus drivers were selected. Instruments for this project were contains: body discomfort chart (BDC), digital scale, stadiometer, anthropometric calipers and chair. Drivers questioned about age, work and their past occupations. Then measuring of weight, length, hand-arm length, popliteal length and height, knee length and height were done. Then the data were analyzed by spearman test on Spss software program.ResultsThe statistic tests result show that: there is a relationship between drivers MSDs and its length, weight and age. That means with increasing of drivers weight and age or shortness in length, MSDs probability will be raised.ConclusionIt seems strain and stretch that driver bears for reaching to vehicle role, age rising and its effects on the person physical condition are their MSDs reasons. Consequently, our recommendation is: on examination for selecting drivers they should be selected among long, thin  and proportional (without over weight) volunteers. This measure can be an effective step toward  preventing drivers MSDs, driving crashes and accidents.