Up to 15 years ago, bibliographic searches based on keywords such as photoreceptor degeneration, inner retina or photoreceptor degeneration, second order neurons returned only a handful of papers, as the field was dominated by the general assumption that retinal degeneration had direct effects on the sole populations of rods and cones. Since then, a number of studies have been dedicated to understanding the process of gradual morphological, molecular and functional changes arising among cells located in the inner retina (comprising neurons, glia and blood vessels), that is to say beyond photoreceptors. General aspects of this progression of biological rearrangements, now referred to as remodeling, were revealed and demonstrated to accompany consistently photoreceptor loss, independently from the underlying cause of degeneration. Recurrent features of remodeling are summarized here, to provide a general frame for to the various analytical descriptions and reviews provided by the articles in the issue (among others, see Stasheff; Goo et al., Puthussery et al.; Fernández-Sánchez et al.; Euler and Schubert; Jones et al.; this issue).